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Stem cell treatment for lower back pain3/30/2023 Here, they developed human iPSC-derived cartilaginous tissue (hiPS-Cart) for implantation into lab rats that had the NP removed from the IVD as a model of IVD degeneration. This method had been successfully used to create repair tissue when implanted into certain animals with articular cartilage defects. Additionally, they can be induced to become chondrocytes, which are cells that produce and maintain cartilage. The researchers used induced pluripotent stem cells (iPSCs) that can become different cell types, because they do not have the growth and division limits of native NP cells. "Thus, we hypothesized that cell types that can produce and support cartilage could be useful for treating IVD degeneration." Interestingly, this composition is similar to the ECM of articular cartilage," says Takashi Kamatani, lead author of the study. "The ECM of the NP is a network of collagen that acts as scaffolding for other important proteins. Therefore, the Osaka University and Kyoto University group aimed to establish a tissue-engineered implant that contains the necessary cells to create and maintain the ECM in the NP. Previous work on treatment methods utilizing native viable NP cells that help produce the ECM has been promising, but these restorative effects are lost in advanced stages of degeneration where these cells are no longer present. The ECM fosters an environment that is supportive of the NP cells, and also helps give the NP its mechanical elasticity. It is believed that IVD degeneration originates in the nucleus pulposus (NP), which is composed of NP cells that produce the surrounding extracellular matrix (ECM).
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